The facts and the project
The human organism produces, constantly and in billions, a huge range of proteins that are intended to protect it. These are antibodies and T receptors, capable of detecting and neutralising viruses, bacteria and other pathogenic agents, as well as cancerous cells. Analysing the DNA sequences of these proteins is essential in understanding their variety and in identifying immunity profiles for normal and pathological situations. This is a highly specific area of research that has been made its own by the Montpellier Laboratoire d’Immunogénétique Moléculaire. It uses the IMGT/HighV-QUEST software that can simultaneously analyse hundreds of thousands of sequences.
The results of this are made available to the scientific and medical communities and pharmaceutical companies through a web-based platform, with increasing success and worldwide visibility, attracting users from every continent. This type of analysis can only be performed using high performance computing, specifically GENCI’s Jade computer: In 2013, 1.4 billion sequences were analysed; at a rate that has been increased to 10 million sequences a day since January 2014. A crucial “system” for fundamental research, clinical diagnoses and prognostics, as well as for the engineering of antibodies for therapeutic uses.
224 000 core hours on Jade and 70 000 on Yoda (Cines)
Principal Investigator: Véronique Giudicelli - Laboratoire d’immunogénétique moléculaire (CNRS)